TORWISE 20 (Torsemide 20mg Tablet)
Torwise tablets contain Torasemide 20 mg respectively. Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfnyl urea used as an antihypertensive agent.
• congestive heart failure
• renal or hepatic diseases
Dosage : As directed by physician
Mechanism of Action
Torasemide is part of the loop diuretics and thus, it acts by reducing the oxygen demand in the medullary thick ascending loop of Henle. Torasemide is known to have an effect in the renin-angiotensin-aldosterone system by inhibiting the downstream cascade after the activation of angiotensin II. This inhibition will produce a secondary effect marked by the reduction of the expression of aldosterone synthase, TGF-B1 and thromboxane A2 and a reduction on the aldosterone receptor binding.
Torasemide is the diuretic with the highest oral bioavailability even in advanced stages of chronic kidney disease. This bioavailability tends to be higher than 80% regardless of the patient condition.
The volume of distribution of torasemide is 0.2 L/kg.
Torasemide is mainly hepatically processed and excreted in the feces from which about 70-80% of the administered dose is excreted by this pathway. On the other hand, about 20-30% of the administered dose is found in the urine.
• Joint disorder
• High amount of triglyceride in the blood
• Hearing loss
• Hardening of the liver
• Dry mouth
• increased thirst
• Muscle cramps
• Loss of hearing