Torsemide 10mg Tablet

TORWISE 10 (Torsemide 10mg Tablet Manufacturer and Supplier)

Torwise tablets contain Torasemide 10 mg respectively. Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfnyl urea used as an antihypertensive agent.

  Indication
• Edema
• congestive heart failure
• renal or hepatic diseases
• Hypertension

  Dosage : As directed by physician

  Mechanism of Action
Torasemide is part of the loop diuretics and thus, it acts by reducing the oxygen demand in the medullary thick ascending loop of Henle. Torasemide is known to have an effect in the renin-angiotensin-aldosterone system by inhibiting the downstream cascade after the activation of angiotensin II. This inhibition will produce a secondary effect marked by the reduction of the expression of aldosterone synthase, TGF-B1 and thromboxane A2 and a reduction on the aldosterone receptor binding.

  Pharmacology
Absorption
Torasemide is the diuretic with the highest oral bioavailability even in advanced stages of chronic kidney disease. This bioavailability tends to be higher than 80% regardless of the patient condition.

Distribution 
The volume of distribution of torasemide is 0.2 L/kg.

Excretion
Torasemide is mainly hepatically processed and excreted in the feces from which about 70-80% of the administered dose is excreted by this pathway. On the other hand, about 20-30% of the administered dose is found in the urine.

  Contraindication
• Joint disorder
• Dehydration
• High amount of triglyceride in the blood
• Hearing loss
• Hardening of the liver

  Precautions
• Dry mouth
• increased thirst
• Muscle cramps
• Dizziness 
• Loss of hearing
• Nausea

Introduction