Z-TEL-C (Telmisartan Chlorthalidone 40mg 12.5mg Tablet)
Z-Tel-C tablet contains Telmisartan 40 mg & Chlorthalidone 12.5 mg. Telmisartan and chlorthalidone, which lowers blood pressure effectively. Telmisartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Chlorthalidone is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
• Control the risk of cardiovascular events such as strokes
• Kidney problems
Dosage : Once a day , dosage is based on your medical condition and response to treatment.
Mechanism of action
Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland.
Chlorthalidone inhibits the reabsorption of sodium at the level of the distal convoluted tubule and thus chloride via inhibition of the Na/Cl symporter. By removing sodium reabsorption at this location, the distal convoluted tubule of the nephron retains a higher sodium content
Rapidly absorbed. Dose dependent bioavailability 42% (after 40 mg dose) Peak plasma concentration: 0.5-1 hr.
Protien binding: 99%. Metabolism: undergoes conjugation with glucuronic acid to form inactive metabolites
Excreted almost entirely as unchanged drug in faeces via bile. <1% excreted via urine
• Severe hepatic impairment
• biliary obstructive disorders
• Hepatic insufficiency
• Renaly artery stenosis
• Biliary obstruction
• Impaired renal function