Telmisartan 40mg Metoprolol Succinate ER 50mg Tablet

Z-TEL-M (Telmisartan 40mg Metoprolol Succinate ER 50mg Tablet Manufacturer and Supplier)

Introduction
Z-Tel-M tablet contains Telmisartan and Metoprolol . This drug is mainly used in loweing the blood-pressure.Telmisartan is an angiotensin receptor blocker (ARB). It works by blocking the chemical angiotensin, thereby relaxing blood vessels.Metoprolol Succinate is a beta blocker which works specifically on the heart to reduce heart rate and lower blood pressure. Together they allow the blood to flow more smoothly and the heart to pump more efficiently.
  Indications
• Hypertension
• Angina pectoris
  Dosage : Dosage, as directed by the physician
  Mechanism of action
Telmisartan
It is angiotensin II type 1 -receptor antagonist. It acts by blocking narrowing of blood vessels(vasoconstriction) of angiotensin II and, blocks binding action to angiotensin I and secretion of aldosterone. Therefore, relaxes blood vessels and reduces blood pressure by increasing oxygen and blood flow to the heart.
Metoprolol succinate
It is a cardio-selective beta blocker drug. This drug acts by preventing Nor-adrenaline/adrenaline hormones in the heart. Therefore reduces the demand for oxygen and lowers the heart rate by relaxing the blood vessels thereby decreasing the blood pressure, and reducing the chest pain.


  Pharmacology
Absorption
After oral administration, Rapidly Absorbed, when it is taken with food.
Distribution
Plasma protein bonded about 99.5% of the drug. The distribution of the drug is approximately 500 liters. Increased volume of distribution indicates more tissue binding.
  Excretion
The drug is excreted with feces, as unchanged compound.
  Contraindication
• Increase potassium level
• Sweating , diarrhea
• Cerebrovascular diseases
• Pulmonary Edema
• Numbness of extremity
• Deceased blood pressure
  Precautions
• Pregnant and lactating women  
• Patients taking potassium supplements 
• Dizziness
• Hepatic and renal impairment patients