Ranolazine Extended Release tab 500mg Tablet

Z-RANO-500 SR (Ranolazine Extended Release tab 500mg Tablet)

Z-Rano 500 consists of Ranolazine 500 mg. Ranolazine is a well-tolerated piperazine derivative used for the management of chronic angina, offering relief from uncomfortable and debilitating symptoms.
  Indications
• Ranolazine is indicated for the treatment of chronic angina
  Mechanism of action
• The mechanism of action for ranolazine is not fully understood. At therapeutic concentrations, it can inhibit the cardiac late sodium 205 current (INa), which may affect the electrolyte balance in the myocardium, relieving angina symptoms. 
  Dosage
As prescribed by the physician.
  Pharmacology
Absorption
The time to reach peak serum concentration is quite variable but has been observed to be in the range of 2-6 hours, with steady-state within 3 days.
Distribution
The mean apparent volume of distribution of ranolazine is reported to be 53.2 L.
Excretion
From the administered dose, about 3/4 of the dose is excreted renally, while 1/4 of the dose is excreted in the feces. 
  Precautions
• Avoid grapefruit products
• Take with or without food. The absorption is unaffected by food

  Contraindications
• Ranolazine is contraindicated in patients with hepatic cirrhosis

Introduction