Nebivolol 5mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise
Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity.
Nebivolol is indicated to treat hypertension.
Dosage : As directed by physician
Mechanism of Action
Nebivolol is a highly selective beta-1 adrenergic receptor antagonist2 with weak beta-2 adrenergic receptor antagonist activity. Blocking beta-1 adrenergic receptors by d-nebivolol leads to decreased resting heart rate, exercise heart rate, myocardial contracility, systolic blood pressure, and diastolic blood pressure.4,2,3,5 The selectivity of d-nebivolol limits the magnitude of beta blocker adverse effects in the airways or relating to insulin sensitivity. Nebivolol also inhibits aldosterone, and beta-1 antagonism in the juxtaglomerular apparatus also inhibits the release of renin. Decreased aldosterone leads to decreased blood volume, and decreased renin leads to reduced vasoconstriction. l-nebivolol is responsible for beta-3 adrenergic receptor agonist activity that stimulates endothelial nitric oxide synthase, increasing nitric oxide levels; leading to vasodilation, decreased peripheral vascular resistance, increased stroke volume, ejection fraction, and cardiac output.
The absorption of nebivolol is not affected by food. Nebivolol has a Tmax of 1.5-4 hours.
For a 20mg dose, d-nebivolol has an apparent volume of distribution of 10,290.81±3911.72L
In extensive CYP2D6 metabolizers, 38% is eliminated in the urine and 44% in the feces.
Nebivolol should also be avoided in patients with cardiogenic shock, acute decompensated heart failure, sick sinus syndrome with no permanent pacemaker, and severe hepatic impairment
Do not take other medicines unless they have been discussed with your doctor.