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Losartan Potassium Amlodipine 50mg 5mg Tablet

Losartan Potassium Amlodipine 50mg 5mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise

Losartan Potassium Amlodipine 50mg 5mg Tablet

Composition : Z-SAR-A

Packing : 10x10

Price : Rs. 650

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Z-SAR-A (Losartan Potassium Amlodipine 50mg 5mg Tablet)

Z-Sar-A tablet is the combination of Losartan Potassium and Amlodipine . Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension and amlodipine is a calcium channel blocker (CCB). They work by relaxing the blood vessels and making the heart more efficient at pumping blood throughout the body.
• Hypertension
• Diabetic Nephropathy
• Risk of stroke
• Heart Faliure
• Coronary artery disease
• Chronic stable angina
• Vasospastic angina

  Dosage : As directed by the physician
  Mechanism of action
Losartan Potassium

Losartan reversibly and competitively prevents angiotensin II binding to the AT1 receptor in tissues like vascular smooth muscle and the adrenal gland. Losartan and its active metabolite bind the AT1 receptor with 1000 times more affinity than they bind to the AT2 receptor. Losartan's prevention of angiotensin II binding causes vascular smooth muscle relaxation, lowering blood pressure. Angiotensin II would otherwise bind to the AT1 receptor and induce vasoconstriction, raising blood pressure.
Amlodipine has a strong affinity for cell membranes, modulating calcium influx by inhibiting selected membrane calcium channels. This drug's unique binding properties allow for its long-acting action and less frequent dosing regimen.
• Losartan Potassium

Losartan is approximately 33% orally bioavailable.
The volume of distribution of losartan is 34.4±17.9L and 10.3±1.1L for the active metabolite (E-3174)
A single oral dose of losartan leads to 4% recovery in the urine as unchanged losartan, 6% in the urine as the active metabolite.3,4 Oral radiolabelled losartan is 35% recovered in urine and 60% in feces. Intravenous radiolabelled losartan is 45% recovered in urine and 50% in feces.
• Amlodipine

Amlodipine absorbed slowly and almost completely from the gastrointestinal tract. Peak plasma concentrations are achieved 6-12 hours after oral administration. The estimated bioavailability of amlodipine is 64-90%.
About 97.5% of the drug is bound to plasma protein. The drug is metabolized by liver.
Amlodipine is 10% excreted as unchanged drug in the urine. 

• Sleepiness
• Ankle swelling
• Increased potassium level in blood
• Taste change
• Dizziness

• Pregnant and lactation
• Not for children use upto age 6
• Swelling
• Patient with liver disorder