Clinidipine Telmisartan 10mg 40mg Tablet

The Clinidipine Telmisartan 10mg 40mg Tablet helps in the treatment of Hypertension. The condition is also termed a case of high blood pressure. The medicine also helps in treating chest pain caused due to heart problems. The tablets are a combination of calcium channel blockers and angiotensin receptor blockers. 
Clinidipine Telmisartan 10mg 40mg Tablet is composed of Clinidipine 20 mg and Telmisartan 40mg. Cilnidipine is a dihydropyridine calcium antagonist. Clinidipine possesses a slow-onset, long-lasting vasodilating effect. Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Precautions with the use of Clinidipine Telmisartan 10mg 40mg Tablets are important. Take the tablets after the approval of a health expert. Avoid taking the dose in the case of any severe medical allergies. People using the tablets may also face some side effects such as nausea, drowsiness, vomiting,  increased heart rates, etc. Pregnant women must avoid the use.

Indications for the use of Z-CILI-T tablets 

Clinidipine Telmisartan 10mg 40mg Tablets are prescribed for:

• Hypertension (High Blood Pressure)
• Reducing the risk of heart-related complications
• Managing chest pain (angina) associated with hypertension
• Improving arterial blood flow

Mechanism of Action

Cilnidipine

Cilnidipine is a dihydropyridine calcium channel blocker that acts on both:

• L-type calcium channels – relaxes blood vessels and reduces pressure
• N-type calcium channels – reduces sympathetic nerve activity and controls stress-induced blood pressure spikes

This dual mechanism makes Cilnidipine effective for sustained blood pressure control.

Telmisartan

Telmisartan is an Angiotensin II Receptor Blocker (ARB) that:

• Blocks the binding of angiotensin II to AT1 receptors
• Prevents blood vessel narrowing
• Reduces aldosterone release
• Lowers sodium and water retention

The result is lower blood pressure and improved cardiac efficiency

Pharmacology

Absorption

• Cilnidipine: Rapid absorption with peak plasma concentration at approx. 2 hours.
• Telmisartan: Bioavailability varies with food intake (slightly decreased by up to 6%).

Distribution

• Cilnidipine distributes widely in the liver, kidneys, and plasma tissues.
• Telmisartan has a high volume of distribution (500 L) indicating extensive tissue penetration.

Excretion

• Cilnidipine: 20% excreted through urine, 80% via feces.
• Telmisartan: Over 97% excreted unchanged in feces (biliary route).

Dosage and Administration 

The dosages of this must be strictly prescribed by doctor; self-medication or overdosing can cause serious 

• Take the dosage strictly as prescribed by the physician.
• Typically taken once daily, with or without food.
• Do not double the dose if you miss one; take it at the next scheduled time.

Side Effects of using Z-CILI-T tablets 

Some users may experience mild and temporary side effects such as:

• Nausea
• Headache
• Drowsiness
• Vomiting
• Low blood pressure
• Digestive discomfort
• Swelling of feet (rare)

Seek medical help if side effects persist or worsen.

Precautions while using Z-CILI-T tablets 

Follow these important precautions:

1. Severe liver disease
2. Cardiogenic shock
3. Recent heart attack
4. Aortic stenosis

• Breathing issues
• Skin allergies
• Kidney problems
• Dehydration

Contraindications

Do NOT use this medication if you have:

• Hypersensitivity to Cilnidipine or Telmisartan
• Severe hypotension
• Cardiogenic shock
• Acute unstable angina
• Severe aortic stenosis

Storage Instructions

• Store in a cool and dry place below 25°C.
• Keep away from sunlight and moisture.
• Keep out of reach of children 

Frequently Asked Qusetions