Clinidipine Telmisartan 10mg 40mg Tablet

Z-CILI-T (Clinidipine Telmisartan 10mg 40mg Tablet)

Introduction
Z-CILI-T C is composed of Clinidipine 20 mg.and Telmisartan 40mg. Cilnidipine is a dihydropyridine calcium antagonist. Clinidipine possesses a slow-onset, long-lasting vasodilating effect. 

Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension
  Indications
• Cilnidipine +Telmisartan is used in the treatment of Hypertension (high blood pressure).
  Mechanism of action
 Cilnidipine acts on the L-type calcium channels and blocks the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also acts on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of nor-epinephrine and decreases the blood pressure.
Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland
  Dosage
As prescribed by the physician.
  Pharmacology
  Absorption
Cilnidipine absorbs very rapidly and attains a maximum peaked concentration after 2 hours. Its distribution tends to be higher in the liver as well as in kidneys, plasma and other tissues. 
Telmisartan’s bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).
  Distribution
Clinidipine’s   distribution is higher in the liver as well as in kidneys, plasma and other tissues. It doesn’t present a high accumulation in the tissue after repeated oral administration. Cilnidipine is reported to present very low bioavailability, approximately 13%.
The Volume of distribution of Telmisartan is 500 L.

  Excretion
Cilnidipine excretes through the urine in a proportion of 20% of the administered dose and 80% is eliminated by the feces. 
Most the Telmisartan’s administered dose (>97%) eliminates unchanged in feces via biliary excretion; only minute amounts were found in the urine 
  Precautions
Inform your physician, if you are
• Cilnidipine is not  safe to  use during pregnancy
• Precautions should be taken  if you have skin allergy or breathing problems 
  Contraindications
• Cardiogenic shock, recent MI or acute unstable angina; severe aortic stenosis