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Clinidipine 10mg Tablet

Clinidipine 10mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise

Clinidipine 10mg Tablet

Composition : Z-CILI-10

Packing : 10x10

Price : Rs. 890

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Z-CILI-10 (Clinidipine 10mg Tablet)

Z-CILI 10 is composed of Clinidipine 10 mg. Cilnidipine is a dihydropyridine calcium antagonist. Clinidipine possesses a slow-onset, long-lasting vasodilating effect. 
  Indications
• Cilnidipine is indicated for the management of hypertension
  Mechanism of action
Cilnidipine acts on the L-type calcium channels and blocks the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also acts on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of nor-epinephrine and decreases the blood pressure.
  Dosage
As prescribed by the physician.
  Pharmacology
  Absorption
Cilnidipine absorbs very rapidly and attains a maximum peaked concentration after 2 hours. Its distribution tends to be higher in the liver as well as in kidneys, plasma and other tissues. 
  Distribution
Clinidipine’s   distribution is higher in the liver as well as in kidneys, plasma and other tissues. It doesn’t present a high accumulation in the tissue after repeated oral administration. Cilnidipine is reported to present very low bioavailability, approximately 13%.
  Excretion
Cilnidipine excretes through the urine in a proportion of 20% of the administered dose and 80% is eliminated by the feces. 

  Precautions
Inform your physician, if you are
• Cilnidipine is not  safe to  use during pregnancy
• Precautions should be taken  if you have skin allergy or breathing problems 
  Contraindications
• Cardiogenic shock, recent MI or acute unstable angina; severe aortic stenosis



Introduction