Clinidipine 10mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise
Z-CILI 10 is composed of Clinidipine 10 mg. Cilnidipine is a dihydropyridine calcium antagonist. Clinidipine possesses a slow-onset, long-lasting vasodilating effect.
• Cilnidipine is indicated for the management of hypertension
Mechanism of action
Cilnidipine acts on the L-type calcium channels and blocks the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. It also acts on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of nor-epinephrine and decreases the blood pressure.
As prescribed by the physician.
Cilnidipine absorbs very rapidly and attains a maximum peaked concentration after 2 hours. Its distribution tends to be higher in the liver as well as in kidneys, plasma and other tissues.
Clinidipine’s distribution is higher in the liver as well as in kidneys, plasma and other tissues. It doesn’t present a high accumulation in the tissue after repeated oral administration. Cilnidipine is reported to present very low bioavailability, approximately 13%.
Cilnidipine excretes through the urine in a proportion of 20% of the administered dose and 80% is eliminated by the feces.
Inform your physician, if you are
• Cilnidipine is not safe to use during pregnancy
• Precautions should be taken if you have skin allergy or breathing problems
• Cardiogenic shock, recent MI or acute unstable angina; severe aortic stenosis