Coradon MR 35

Coradon MR-35 (Trimetazidine hydrochloride 35 mg) is an advanced metabolic anti-anginal formulation designed to optimize cardiac energy utilization and protect heart muscle cells under ischemic conditions. It is widely used as an adjunct therapy in the management of stable angina, helping improve exercise tolerance and reduce the frequency of anginal episodes. By enhancing myocardial efficiency without affecting heart rate or blood pressure, it offers a unique cardioprotective approach.Trimetazidine dihydrochloride­ modified release tablet is widely used to treat angina pectoris, a condition marked by chest pain due to reduced blood flow to the heart. It is designed in a modified-release formulation, which ensures gradual and controlled release of the drug into the bloodstream. It is an anti-anginal medicine which is used in combination with other medicines to treat angina pectoris. Trimetazidine dihydrochloride­ helps the heart work more efficiently by improving how it uses oxygen. This medication prevents new attacks of angina but does not stop an acute attack. It may be classified as a coronary vasodilator, which works by relaxing the smooth muscle of arteries and veins, allowing blood flow to occur more freely. 

How Does Coradon MR-35 (Trimetazidine hydrochloride 35 mg)  Work?

Coradon MR-35  (Trimetazidine hydrochloride 35 mg)  works through a metabolic modulation mechanism, rather than direct hemodynamic action:

• work by inhibiting an enzyme called 3-KAT, which shifts cardiac cell metabolism during ischemia from fatty acid oxidation to the more efficient glucose oxidation. 
• Support in glucose oxidation, which requires less oxygen for energy production
• Helps maintain intracellular ATP levels, ensuring optimal cellular function
• Reduces intracellular acidosis and calcium overload during ischemia
• Protects cardiac cells from oxidative stress and free radical damage

Clinical Benefits of Coradon MR-35 (Trimetazidine hydrochloride 35 mg)

The tablet helps patients manage their condition and engage in daily activities with less fear of chest pain episodes, ultimately enhancing their quality of life.

A List of Medical Benefits of Using Coradon MR-35 (Trimetazidine dihydrochloride­ )Tablets is given as follows: 

• Reduces the frequency and severity of angina attacks
• Helps improve exercise tolerance and cardiac function
• Provides supportive therapy for ischemic heart disease
• Along with that, it also protects heart cells from oxidative stress
• Decreases need for nitrate consumption
•  Supports improved left ventricular function in cardiac patients
•  Beneficial as add-on therapy with standard anti-anginal drugs

Dosage & Administration 

Coradon MR-35  (Trimetazidine dihydrochloride­ ) is usually taken as one tablet twice a day, ideally with meals in the morning and evening to support better absorption and consistent effect. The tablet should be swallowed whole with water and should not be crushed or chewed, as this may interfere with its modified-release action. In patients with kidney-related concerns, the dose may need adjustment based on medical advice. It is also recommended that the treatment is reviewed by a healthcare professional after about three months to assess how well it is working and whether any changes are needed. 

Disclaimer 

Use only as prescribed by a healthcare professional. Not for acute angina relief. Use with caution in renal impairment or movement disorders. Do not exceed the recommended dose. Keep out of reach of children and store in a cool, dry place.