Sacubitril + Valsartan

Sacubitril and Valsartan Tablet is a potent medication specifically formulated to treat heart failure, and reduces the risk of death due to long-lasting (chronic) heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should. This medication is composed of a combination of drugs, namely: Sacubitril and Valsartan, that work together to relax blood vessels, reduce stress on the heart, and enhance healthy blood flow.

Sacubitril belongs to a class of drugs known as neprilysin inhibitors. It works by relaxing and widening the blood vessels and making it easier for the heart to pump blood to all body parts, while Valsartan is an angiotensin II receptor blocker (ARB). It blocks the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly. 

This tablet works by balancing vasodilation, reducing sodium retention, and lowering blood pressure. Additionally, it provides comprehensive support for heart health. Arlak Corazon is a leading and fastest-growing PCD Pharma Franchise. Partner with us to offer Sacubitril and Valsartan Tablet, marketed under the brand name VALCUB-50, a trusted heart failure medication. 

What is the Working Mechanism for the Sacubitril and Valsartan Tablet? 

In heart failure, the body responds in a harmful way by activating a system called the renin-angiotensin-aldosterone system (RAAS). Hence, it causes blood vessels to tighten, raises blood pressure, increases certain hormones like aldosterone, and makes the nervous system more active. Simultaneously, the natriuretic peptide system is activated. 

Sacubitril is a pro-drug that inhibits neprilysin, an enzyme responsible for breaking down natriuretic peptides, leading to vasodilation and fluid balance. On the other hand, Valsartan blocks the actions of angiotensin II, a hormone that constricts blood vessels and promotes salt retention. Together, the tablet effectively reduces cardiac stress. 

Medical Benefits of Using Sacubitril and Valsartan Tablet

A List of Medical Benefits of using the Sacubitril and Valsartan Tablet is highlighted as follows: 

• This combination is primarily used to treat chronic heart failure in adults with reduced ejection fraction. 
• The tablet also helps to reduce the risk of cardiovascular death and heart failure hospitalizations.
• The tablet helps to manage blood pressure and improve exercise tolerance
• In addition, it also helps your body retain less water.
• Sacubitril and valsartan are also used to treat symptomatic heart failure in children who are at least 1 year old.

By effectively targeting two neurohormonal systems involved in heart failure progression, it helps to vasodilate blood vessels, reduce strain on the heart, and decrease fluid retention, hence reducing the cardiac stress and risk of death from heart failure. 

Possible Side Effects of Using Sacubitril and Valsartan Tablets

Understanding the potential adverse effects of these tablets is crucial for ensuring safe and effective treatment. 

A list of possible side effects has been highlighted as follows: 

• Low blood pressure (Hypotension)
• Dizziness
• Cough
• Increased potassium level (hyperkalemia)
• Acute renal failure
• Increased creatinine level in the blood

Safety and Precautions

Disclose your previous or recent health issues to your healthcare provider. Consult your healthcare provider in case you feel discomfort. 

Follow the mentioned below, safety, and precautions to avoid any discomfort and adverse effects. 

• Inform your doctor about any history of kidney or liver disease, diabetes, or allergies.
• Do not use if you are pregnant, planning pregnancy, or breastfeeding.
• Avoid potassium supplements or salt substitutes containing potassium without a doctor’s advice.
• Regular monitoring of blood pressure, kidney function, and serum potassium levels is essential.

How to Store Sacubitril and Valsartan Tablets? 

Follow the Instructions mentioned below as follows: 

• Store in a cool, dry place below 30°C. 
• Keep out of reach of children.
• Protect from light and moisture. 
• Keep the tablet blister strip in the outer carton until use. 

Frequently Asked Questions (FAQ’s)

Q1: What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose.

Q2: Is it normal to feel dizzy, especially when standing up?

Dizziness and lightheadedness, particularly when standing up quickly, are common side effects as the medication lowers your blood pressure.

Q3: Can it be used in patients with high blood pressure alone?

No, it is specifically indicated for heart failure with reduced ejection fraction.