Atorvastatin & Fenofibrat Tablets

Atorvastatin and Fenofibrate Tablets- The Tablets are related to that class of drugs that are known as lipid-lowering medications. These medicines are used to treat high cholesterol in patients. Additionally, this drug is also used to treat symptoms of heart disorders and blockage of blood vessels. This combination of medicines is beneficial for treating hyperlipidemia, a kind of health issue in patients in which levels of bad cholesterol are increased, and the good cholesterol is decreased. This leads patients to the risk of heart attacks and stroke.

Atorvastatin and Fenofibrate tablets include Atorvastatin 10mg and Fenofibrate 160 mg. Atorvastatin belongs to the ‘statin’ class of drugs. These drugs are used to maintain the lipid profile and prevent the events associated with cardiovascular diseases.  On the other hand, fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, and lipoprotein B while increasing high-density lipoprotein cholesterol. Arlak Corazon is a leading manufacturer of Atorvastatin and Fenofibrate, which are sold under the brand name Coravas-FB Tablet. 

What is the Mechanism of Action for Atorvastatin and Fenofibrate Tablets?

The mechanism of action of Atorvastatin and Fenofibrate Tablets is explained as follows:

Atorvastatin produces its action by acting as an inhibitor of HMG Co, an enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is a precursor of cholesterol and sterols. 

Whereas Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPARα), increasing lipolysis, activating lipoprotein lipase, and reducing apoprotein C-III.8, 11, 12 PPARα is a nuclear receptor, and its activation alters lipid, glucose, and amino acid homeostasis.

Dosage With The Use Of Atorvastatin and Fenofibrate Tablets

Patients should use this medication only after recommendations from professional healthcare providers and never self-medicate; otherwise, they may face some common side effects with use.

Pharmacology Absorption of Atorvastatin and Fenofibrate Tablets

The Pharmacology Absorption of Atorvastatin and Fenofibrate Tablets is explained as follows:

Atorvastatin attains its peak plasma concentration in 1-2 hrs after oral administration. The bioavailability of the drug is approximately 14%. 

The presence of food affects drug availability. And on the other hand, A single 300mg oral dose of fenofibrate reaches a Cmax of 6-9.5 mg/L with a Tmax of 4-6 h in healthy, fasting volunteers.

Medical Benefits of Using Atorvastatin and Fenofibrate Tablets

The benefits of using Atorvastatin and Fenofibrate Tablets have been mentioned as follows:

• Lowers LDL cholesterol, reducing the risk of heart attacks and strokes.
• Decreases triglyceride levels, improving overall lipid profile and cardiovascular health.
• Reduces the risk of pancreatitis in patients with severely elevated triglyceride levels through effective lipid control.
• Improves overall cholesterol balance when both cholesterol and triglycerides are high.
• Increases good cholesterol, which protects arteries from fatty buildup over time.

Safety Measures and Precautions to Follow While Using Atorvastatin and Fenofibrate Tablets

A list of safety measures and precautions to follow while using this combination of Atorvastatin and Fenofibrate Tablets has been mentioned as follows:

• Patients with hepatic dysfunction should not use this medication.
• This drug increases fasting glucose levels with use.
• Pregnant and lactating mothers used the advice of a doctor.
• This medication may show Contraindications with other drugs, so be careful while using it.
• Patients with Hypersensitivity to any of the ingredients cannot use this medicine.
• The patient should complete the course of Atorvastatin and Fenofibrate Tablets.
• Patients should never be prescribed to other patients who are suffering from different diseases.
• This medication is not for use in children.

How to Store the Atorvastatin and Fenofibrate Tablets?

Follow the instructions mentioned below:

• Store the Atorvastatin and Fenofibrate Tablets in a cool, dry place (25-28 °C)
• Protect it from light and moisture.
• Keep it away from the children and pets.
• Do not freeze the tablets.
• Do not use the Atorvastatin and Fenofibrate Tablets after the expiry date.