Atorvastatin & Fenofibrat Tablets - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise
Atorvastatin+ Fenofibrate tablets are related to that class of drugs that are known as lipid-lowering medications. These medicines are used to treat high-level cholesterol in the body of patients. Additionally, this drug is also used to treat symptoms of heart disorders, and blockage of blood vessels. This combination of medicine is beneficial to treat hyperlipidemia, a kind of health issue in patients in which levels of bad cholesterol, are increased and decreased the good cholesterol. This leads patients to the risk of heart attacks, and stroke.
Atorvastatin+ Fenofibrate tablets include Atorvastatin 10mg and Fenofibrate 160 mg. Atorvastatin belongs to the ‘statin’ class of drugs. These drugs are used in maintaining the lipid profile and prevent the events associated with cardiovascular diseases. On the other hand, fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, and lipoprotein B while increasing high-density lipoprotein cholesterol.
Brand name: Coravas-FB
Manufacturer: Corazon Pharma
Composition: Atorvastatin 10mg and Fenofibrate 160 mg.
Packaging Type: Blisters
Country of origin: India
Treatment: High Cholesterol
Form of Medication: Tablet
Type Of medication: Allopathic
Usage: Medical/ Clinical
Atorvastatin produces its action by acting as HMG Co an enzyme inhibition that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is a precursor of cholesterol and sterols. And Fenofibrate activates peroxisome proliferator-activated receptor alpha (PPARα), increasing lipolysis, activating lipoprotein lipase, and reducing apoprotein C-III.8, 11, 12 PPARα is a nuclear receptor and its activation alters lipid, glucose, and amino acid homeostasis.
Patients should use this medication only after recommendations of professional healthcare providers, and never self-medicate the dose of medication otherwise you may face some common side effects with use.
Atorvastatin attains its peak plasma concentration attains in 1-2 hrs after oral administration. The bioavailability of the drug is approximately 14%. The presence of food affects drug availability. And on the other hand, A single 300mg oral dose of fenofibrate reaches a Cmax of 6-9.5mg/L with a Tmax of 4-6h in healthy, fasting volunteers.
Atorvastatin’s nearly about 98% the drug is bound to plasma protein. The drugs produce their action by forming their metabolites. The volume of distribution of fenofibrate is 0.89L/kg,4, and can be as high as 60L.
After pharmacological action atorvastatin is excreted through bile. The elimination half-life is 14 hrs.5-25% of a dose of fenofibrate is eliminated in the feces, while 60-88% is eliminated in the urine.
Atorvastatin+ Fenofibrate tablets show many common side effects with use and the following are some adverse effects.
Hypersensitivity to the active substance or to any of the excipients, and following are some names of drugs that can interact with Atorvastatin+ Fenofibrate tablets.