Olmesartan 20mg Hydrochlorothiazide 12.5mg Tablet

OLMEZON-20H (Olmesartan 20mg Hydrochlorothiazide 12.5mg Tablet)

Introduction
Olmezon 20 H tablets contains  Olmesartan medoxomil and Hydrochlorothiazide.
Olmesartan medoxomil used to reduce the hypertension and antagonize the action of angiotensin II receptor.
Hydrochlorothiazide is a thiazide diuretic that prevent the body to absorb salt that causes fluid retention.
  Indication
• Reduces hypertension
• It reduces the risk of fatal and nonfatal cardiovascular events
• Cardiovascular risk management
• Myocardial infraction
  Dosage : Once a day
  Mechanism of action
Olmesartan-H tablet is a combination of anti-hypertensive and diuretic.
Olmesartan medoxomil  inhibits the binding of angiotensin II to AT I. This causes AT I mediated vasoconstriction that decrease in the blood resistance and blood pressure.
Hydrochlorothiazide is  a thiazide diuretic which produces its action on renal tubular electrolyte reabsorption. It also causes increase in the excretion of sodium and chloride ions.  It also causes increase in the secretion of aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.

  Pharmacology
• Olmesartan medoxomil
  Absorption
The drug after oral administration is bioactivated by ester hydrolysis to olmesarton and which causes absorption from gastrointestinal tract.
  Distribution
The volume of distribution for the drug is about 17 ltrs. The drug is mainly bound to plasma protein and causes its penetration in red blood cells.
  Excretion
The drug is mainly excreted through urine and feces.
• Hydrochlorothiazide
  Absorption
After oral administration about 50 – 60% of the drug gets absorbed.
  Distribution
About 67.9% of the drug is bound to plasma protein.
  Excretion
The drug follows renal excretion.
  Contraindications
• Absence of urine formation
• Acid base imbalance
• Abnormal low blood pressure
• Inflammation of pancreas
• Kidney problem
  Precautions
• Drugs only to taken only under prescription of physician
• Allergic to any drug or its combination
• Renal disorder
• Only to be used when prescribed