CORAVAS GOLD 20 (Atorvastatin, Clopidogrel Bisulphate and Aspirin Capsules)

CORAVAS Gold 20 includes Atorvastatin 10mg, Clopidogrel 75 mg and Aspirin 75 mg.
Atorvastatin belongs to ‘statin’ class of drugs. These drugs are used in maintaining the lipid profile and prevents the events associated with cardiovascular diseases.
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.
Aspirin is used to prevent a first heart attack in people with heart disease risk factors, such as diabetes and high cholesterol.

Mechanism of Action

Atorvastatin: Inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis, leading to reduced LDL cholesterol and triglycerides and modestly increased HDL cholesterol. This slows atherosclerotic plaque formation and improves vascular health.
Clopidogrel Bisulphate: A thienopyridine derivative that irreversibly blocks P2Y12 receptors on platelets, preventing ADP-mediated platelet activation and aggregation. This reduces the risk of arterial thrombosis.
Aspirin: Irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, suppressing thromboxane A2 production, further reducing platelet aggregation.
The combined action of these three agents addresses hyperlipidemia, platelet hyperactivity, and thrombotic risk, providing comprehensive cardiovascular protection.

Indications for Use

CORAVAS GOLD 20 is indicated for:

Patients with high risk of cardiovascular events (heart attack, stroke)
Secondary prevention in patients with established coronary artery disease or atherosclerosis
Management of hyperlipidemia in patients with cardiovascular risk factors
Prevention of arterial thrombosis in post-angioplasty or post-stent placement patients
Patients requiring dual or triple therapy for combined lipid and platelet management

Dosage and Administration

Normally, the recommended dosage must be according to the doctor's prescription and advice

Recommended dose: One capsule once daily or as prescribed by a physician.
Take the capsule preferably after meals with water to reduce gastrointestinal discomfort.
Dosage may be adjusted based on lipid profile, platelet function tests, and clinical response.
Regular monitoring of liver function, renal function, and bleeding parameters is recommended during therapy.

Possible Side Effects

Common and mild side effects may include:

Gastrointestinal disturbances: nausea, abdominal pain, or dyspepsia
Headache, dizziness, or fatigue
Muscle pain or myalgia (from atorvastatin)
Increased bleeding tendency (from Clopidogrel and Aspirin)
Rare: liver enzyme elevation, hypersensitivity reactions, or gastrointestinal ulcers

Patients should report persistent muscle pain, jaundice, or unusual bleeding/bruising immediately.

Precautions

Avoid use in patients with active bleeding, peptic ulcer disease, or severe hepatic impairment.
Use cautiously in patients with renal dysfunction, bleeding disorders, or history of stroke.
Avoid concomitant use with other NSAIDs unless prescribed.
Pregnancy and lactation: Use only if clearly indicated by a physician.
Inform your doctor about any upcoming surgery or invasive procedure due to increased bleeding risk.