Telmisartan 40 mg
Brand Name: – Z-TEL-40TAB (TELMISARTAN 40 mg)
Composition: – Each tablet 40mg Telmisartan
Packing: – 10*10
1. Pharmacodynamics: – Antagonizes the effect of angiotensin II (vasoconstriction and aldosterone secretion) by blocking the angiotensin II (AT 1 receptor) in vascular smooth muscle and the adrenal gland, producing decreased BP.
2. Pharmacokinetics: –
a.) Absorption: – T max is 0.5 to 1 h. Food slightly reduces bioavailability of telmisartan, with an AUC reduction of approximately 6% with a 40 mg dose and 20% with a 160 mg dose. At 40 and 160 mg, the bioavailability was 42% and 58%, respectively. Trough plasma concentrations with daily dosing are approximately 10% to 25% of C max.
b.) Distribution: -Telmisartan is more than 99.5% protein bound. Vd is approximately 500 L.
c.) Metabolism: -Telmisartan is metabolized by conjugation to form a pharmacologically inactive acyl glucuronide. The glucuronide of the parent compound is the only metabolite that has been identified in human plasma and urine.
d.) Elimination: -Telmisartan half-life is approximately 24 h and total plasma Cl is more than 800 mL/min. After IV or oral administration, more than 97% is eliminated unchanged in feces via biliary excretion.
Indications Treatment of hypertension; for the reduction of the risk of MI, stroke, or death from CV causes in patients 55 y and older who are at high risk of developing major CV events and are unable to take ACE inhibitors.