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Pioglitazone 15 mg Tablet

Pioglitazone 15 mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise

Pioglitazone 15 mg Tablet

Composition : COGLIT 15

Packing : 10x10

Price : Rs. 390

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COGLIT 15 (Pioglitazone 15 mg Tablet)


Introduction
Coglit 15 tablets contains Pioglitazone 15mg. Pioglitazone is an antihyperglycemic agent used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus. It works by increasing the body's sensitivity to insulin, a natural substance that helps control blood sugar levels.

  Indication
• Glycemic control
• Type 2 Diabetes mellitus

  Dosage : As directed by Physician

  Mechanism of action
Pioglitazone is a selective agonist at peroxisome proliferator-activated receptor-gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPARγ increases the transcription of insulin-responsive genes involved in the control of glucose and lipid production, transport, and utilization.

  Pharmacology
  Absorption
Oral administration of pioglitazone, peak serum concentrations are observed within 2 hours, food slightly delays the time to peak serum concentration, increasing time to approximately 3-4 hours, but does not alter the extent of absorption.
  Distribution
The average apparent volume of distribution of pioglitazone is 0.63 ± 0.41 L/kg. 
  Excretion
Approximately 15-30% of orally administered pioglitazone is recovered in the urine. The bulk of its elimination, then, is presumed to be through the excretion of unchanged drug in the bile or as metabolites in the feces.

  Contraindications
• Blurred Vision
• Weight gain
• Respiratory Tract infection
• Numbness
• Bone fracture

  Precautions
• During Pregnancy and lactation
• Stimulate ovulation in a premenopause woman
• Risk of Bladder cancer
• Patient with heart related problem