Nitroglycerine 6.4mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise
CORCONT (Nitroglycerine 6.4mg Tablet)
CORCONT 6.4 mg is composed of Nitroglycerine 6.4 mg. Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure.
4. It is indicated to prevent and treat angina or chest pain due to cardiovascular disease
5. It is also indicated to treat peri-operative hypertension or induce intra-operative hypotension
6. It is also indicated to treat acute heart failure in patients with myocardial infarction
Mechanism of action
Nitroglycerine is converted by mitochondrial aldehyde dehydrogenase (mtALDH) to nitric oxide (NO), an active substance which then activates the enzyme guanylate cyclase. The activation of this enzyme is followed by the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP), activating a cascade of protein kinase-dependent phosphorylation events in smooth muscles.
As prescribed by the physician.
Nitroglycerine is rapidly absorbed and is often used in emergency situations for this reason. After a sublingual dose of 0.5 mg of nitroglycerin, peak concentration reaches by an average of in 4.4 minutes after administration and measured to be 2.56 ng/ml.
The volume of distribution of nitroglycerin is 3 L/kg
Metabolism is the main route by which nitroglycerin is eliminated from the body
Inform your physician, if you are
• Nitroglycerine sublingual tablets should not be chewed, crushed, or swallowed. They work much faster when absorbed through the lining of the mouth.
• Place the tablet under the tongue or between the cheek and gum, and let it dissolve.
• Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving
• Nitroglycerine is contraindicated in patients that have reported allergic symptoms to the medication.
• Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerine are all contraindications to nitroglycerine therapy