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Nitroglycerine 6.4mg Tablet

Nitroglycerine 6.4mg Tablet - Manufacturers & Suppliers - Third Party Contract Manufacturing - PCD Pharma Franchise

Nitroglycerine 6.4mg Tablet

Composition : CORCONT

Packing : 10x10

Price : Rs. 159

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CORCONT (Nitroglycerine 6.4mg Tablet)

CORCONT 6.4 mg is composed of Nitroglycerine 6.4 mg. Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure.
  Indications
4.  It is indicated to prevent and treat angina or chest pain due to cardiovascular disease
5.  It is also indicated to treat peri-operative hypertension or induce intra-operative hypotension
6.  It is also indicated to treat acute heart failure in patients with myocardial infarction
  Mechanism of action
Nitroglycerine is converted by mitochondrial aldehyde dehydrogenase (mtALDH) to nitric oxide (NO), an active substance which then activates the enzyme guanylate cyclase.  The activation of this enzyme is followed by the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP), activating a cascade of protein kinase-dependent phosphorylation events in smooth muscles.
  Dosage
As prescribed by the physician.
  Pharmacology
  Absorption
Nitroglycerine is rapidly absorbed and is often used in emergency situations for this reason.  After a sublingual dose of 0.5 mg of nitroglycerin, peak concentration reaches by an average of in 4.4 minutes after administration and measured to be 2.56 ng/ml.
  Distribution
The volume of distribution of nitroglycerin is 3 L/kg
  Excretion
Metabolism is the main route by which nitroglycerin is eliminated from the body
  Precautions
Inform your physician, if you are
• Nitroglycerine sublingual tablets should not be chewed, crushed, or swallowed. They work much faster when absorbed through the lining of the mouth.
• Place the tablet under the tongue or between the cheek and gum, and let it dissolve.
• Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving
  Contraindications
• Nitroglycerine is contraindicated in patients that have reported allergic symptoms to the medication.
• Known history of increased intracranial pressure, severe anemia, right-sided myocardial infarction, or hypersensitivity to nitroglycerine are all contraindications to nitroglycerine therapy


Introduction