Metoprolol 50 mg
BRAND NAME: – Z-MET-50 SR TABLET (Metoprolol 50 mg)
Composition: – Each tablet contains 50mg Metoprolol
1. Pharmacodynamics: – Metoprolol, a competitive, beta1-selective (cardioselective) adrenergic antagonist, is similar to atenolol in its moderate lipid solubility, lack of intrinsic sympathomimetic activity (ISA), and weak membrane stabilizing activity (MSA).
Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
2. Pharmacokinetics: –
a.) Absorption: – Rapid and complete, 50%
b.) Protein Binding: – 12%
c.) Metabolism: – Primarily hepatic
d.) Route of Elimination: – Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity.
e.) Half-Life: – 3-7 hours
Indications: – For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.