Clinidipine Telmisartan 10mg 40mg Tablet

The Clinidipine Telmisartan 10mg 40mg Tablet helps in the treatment of Hypertension. The condition is also termed a case of high blood pressure. The medicine also helps in treating chest pain caused due to heart problems. The tablets are a combination of calcium channel blockers and angiotensin receptor blockers. 
Clinidipine Telmisartan 10mg 40mg Tablet is composed of Clinidipine 20 mg and Telmisartan 40mg. Cilnidipine is a dihydropyridine calcium antagonist. Clinidipine possesses a slow-onset, long-lasting vasodilating effect. Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Precautions with the use of Clinidipine Telmisartan 10mg 40mg Tablets are important. Take the tablets after the approval of a health expert. Avoid taking the dose in the case of any severe medical allergies. People using the tablets may also face some side effects such as nausea, drowsiness, vomiting,  increased heart rates, etc. Pregnant women must avoid the use.

Indication of Clinidipine Telmisartan 10mg 40mg Tablets

Cilnidipine +Telmisartan is used in the treatment of Hypertension (high blood pressure).

Mechanism of Clinidipine Telmisartan 10mg 40mg Tablets

Cilnidipine acts on the L-type calcium channels blocks the incoming calcium and suppresses the contraction of blood vessels, thereby reducing blood pressure. It also acts on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of nor-epinephrine and decreasing blood pressure.

Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1 receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland.

Dosage- As prescribed by the physician.

Pharmacology of Clinidipine Telmisartan 10mg 40mg Tablets

Absorption of Clinidipine Telmisartan 10mg 40mg Tablets

Cilnidipine absorbs very rapidly and attains a maximum peaked concentration after 2 hours. Its distribution tends to be higher in the liver as well as in kidneys, plasma, and other tissues. 

Telmisartan’s bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).

Distribution of Clinidipine Telmisartan 10mg 40mg Tablet

Clinidipine’s distribution is higher in the liver as well as in kidneys, plasma, and other tissues. It doesn’t present a high accumulation in the tissue after repeated oral administration. Cilnidipine is reported to present very low bioavailability, approximately 13%.

The Volume of distribution of Telmisartan is 500 L.

Excretion of Clinidipine Telmisartan 10mg 40mg Tablet
Cilnidipine excretes through the urine in a proportion of 20% of the administered dose and 80% is eliminated by the feces. 

Most the Telmisartan’s administered dose (>97%) eliminates unchanged in feces via biliary excretion; only minute amounts were found in the urine 

Precautions with Clinidipine Telmisartan 10mg 40mg Tablet

There are certain necessary precautions with the use of Clinidipine Telmisartan 10mg 40mg Tablets. Frequent use may also lead to side effects. 

• Inform your physician, if you are
• Cilnidipine is not  safe to  use during pregnancy
• Precautions should be taken if you have skin allergies or breathing problems 

Contraindications-

We recommend to follow a healthy diet and avoid the use of any other drug in combination. 
Cardiogenic shock, recent MI or acute unstable angina; severe aortic stenosis

Side effects of Clinidipine Telmisartan 10mg 40mg Tablet

There are some common occurring after-effects of the use of these tablets. We have mentioned these below.

• Nausea
• Headache
• Drowsiness
• Vomiting
• Digestive issues

Note- the Clinidipine Telmisartan 10mg 40mg Tablet is only for external use.

Storage- Keep the Clinidipine Telmisartan 10mg 40mg Tablet stored in a cool and dry place.