Trimetazidine Dihydrochloride 35 mg ( Coradon MR-35 MG )
MEDICATION USED FOR
Trimetazidine ( Coradon MR-35 ) is used for long term treatment of angina. Angina is chest pain arising from the heart muscle when it does not receive enough oxygen. You may have the feeling of indigestion, fullness, pressure or tightness in the chest spreading to your arms or neck. Trimetazidine(Coradon-MR 35 ) makes better use of oxygen and energy in the heart cells. This helps to decrease the number of times you get angina.
Trimetazidine is indicated for use in angina pectoris.
MECHANISM OF ACTION
Trimetazidine (Coradon MR-35 )is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity, which results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. High fatty acid oxidation rates are detrimental during ischemia due to an inhibition of glucose oxidation leading to uncoupling of glycolysis and an increase in proton production, which has the potential to accelerate sodium and calcium overload in the heart. This leads to an exacerbation of ischemic injury and decreased cardiac efficiency during reperfusion.