Amlodipine 5mg + Atenolol 50 mg
BRAND NAME: MOLD-AT TABLET (Amlodipine 5mg + Atenolol 50 mg)
Composition: – Each tablet contains 5mg of Amlodipine and 50mg of Atenolol
Packing: – 20*10 (Blister)
Atenolol is a cardioselective beta blocker.
Amlodipine is a dihydropyridine calcium-channel blocker that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
Combination of the two drugs results in additive antihypertensive action.
Absorption: Amlodipine: Plasma levels peak 6-12 hr after oral admin; absolute bioavailability is estimated to be 64-90%.
Absorption is rapid and consistent but incomplete; about 50% of an oral dose is absorbed in the GI tract; plasma levels peak 2-4 hr after oral admin.
Distribution: Amlodipine: 93% bound to plasma proteins. Atenolol: 6-16% bound to plasma proteins.
Metabolism: Amlodipine: About 90% converted to inactive metabolites hepatically. Atenolol: Little or no hepatic metabolism.
Excretion: Amlodipine: 10% of parent compound and 60% of the metabolites are removed in the urine;
Elimination from the plasma is biphasic with terminal half-life of about 30-50 hr. Atenolol: 50% of the oral dose is removed unchanged in the faeces; absorbed drug is removed mainly via renal elimination; half-life is about 6-7 hr.
- Treating high blood pressure or chest pain caused by angina.
Atenolol tablets are a beta-blocker. It decreases the action of certain chemicals on the heart and blood vessels. This makes the heart beat more slowly and with less force.