BRAND NAME :- CORAVOG-0.3 M
COMPOSITION:- Metformin Hydrochloride Prolonged – release & Voglibose tablets
MEDICATION USED FOR
Metformin HCL ( Coravog-0.3M) helping to restore your body proper response to the insulin you naturally produce. Metformin also decreases the amount of sugar that your liver makes and that your stomach/intestines absorb . Metformin HCL ( Coravog-0.3M) used with a proper diet and exercise program and possibly with other medication to control high blood sugar Metformin (Coravog-0.3 M) used in patients with type-2 diabetes .Controlling high blood sugar helps prevent kidneys damage blindness,nerve problem, loss of limbs and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attacks or stroke . Metformin HCL( Coravog-0.3 M) also prediabetes , gestational diabetes and Pcos.
Voglibose:- Voglibose an alpha- glucosidase inhibitors used for lowering post-prandial blood glucose levels in people with diabetes mellitus. Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications.
MECHANISM OF ACTION
Metformin HCL& Voglibose (Coravog-0.3 m) decreases hepatic glucose production decreases hepatic glucose production , and improves insulin sensitivity by increasing peripheral glucose uptake and amount of sugar your liver releases into your blood. Metformin HCL & Voglibose ( Coravog-0.3m) also makes your body respond better to insulin . Insulin hormone that control the levels of sugar in your blood. Metformin HCL & Voglibose potent antihyperglycemic agent widely used in the management of type-2 diabetes whose main action are the suppression of glycogenesis and the improvement of glucose uptake and insulin sensitivity . Metformin decreases hepatic glucose production ,decreases intestinal absorbtion of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization .Metformin HCL is a type of antidiabetic medicines . Metformin works in number of ways to lower blood sugar levels in people with type-2 diabetes . Firstly it increases the sensitivity of muscle cells to insulin. Secondly ,it reduces the amount of sugar produced by cells in the liver.
Voglibose an alpha-glycosidase inhibitors.Alpha glucosidase inhibitor delays the glucose absorption at the intestine level and prevent sudden increase of glucose after meal. The drug exerts its anti- hyperglycemic actions by producing reversible competitive inhibitions of alphaglucosidase hydrolase enzyme , glycoamylase sucrose etc which are the final enzyme in the carbohydrate digestion in the brush border of small intestinal mucosa.
Voglibose reduces digestation and absorption of polysaccharides and sucrose , Voglibose should be administered in conjuction with diet plus a sulfonylurea. Voglibose delays and reduces glucose absorption and lowers post prandial hyperglycaemia.