Ivacardia -5 MG ( Ivabradine 5 mg ) IVABRADINE 5 MG ( IVACARDIA -5 ) MEDICATION USED FOR Ivabradine 5 mg ( Ivacardia 5 mg ) medication is used to treat heart failure. It is used by adults to help prevent the heart failure from getting worse and needing treatment in a hospital. It is also used by children who have heart failure due to an enlarged heart (dilated cardiomyopathy). … Ivabradine works by making your heart beat more slowly. INDICATION Ivabradine is indicated by the FDA to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction ≤35%, who are in sinus rhythm with resting heart rate ≥70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use. It is also indicated for treatment of stable symptomatic heart failure as a result of dilated cardiomyopathy for pediatric patients 6 months of age or more.. MECHANISM OF ACTION Ivabradine is a heart-rate-lowering agent that acts by selectively and specifically inhibiting the cardiac pacemaker current (If), a mixed sodium-potassium inward current that controls the spontaneous diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate. The molecular channel belongs to the HCN family.10 Inhibition of this channel disrupts If ion current flow, thereby prolonging diastolic depolarization, slowing firing in the SA node, and ultimately reducing the heart rate. The cardiac effects of ivabradine are specific to the SA node, and the drug has no effect on blood pressure, intracardiac conduction, myocardial contractility, or ventricular repolarization.